A system is provided having a generally sealed cabinet and separator. A blower is provided in the sealed cabinet to provide a negative pressure within the cabinet. A waste entrance is provided in the cabinet which provides a sealed, rotatable input for the introduction of hospital waste to the system. In the system, the input rotates upon operation of a switch to direct solid waste to a disintegrator, such as a hammermill, wiht a flow of disinfectant fluid. Upon disintegration, the waste particles and disinfectant fluid are carried to the separator which is sealed with the cabinet. The solid waste is separated from the decontaminant fluid which is then directed to a public sewer.